Biomarkers for the effects of benzodiazepines in healthy volunteers.

  title={Biomarkers for the effects of benzodiazepines in healthy volunteers.},
  author={Saco J de Visser and Jeroen van der Post and Paul P. de Waal and Francois H. Cornet and Adam F Cohen and Joop M A van Gerven},
  journal={British journal of clinical pharmacology},
  volume={55 1},
Studies of novel centrally acting drugs in healthy volunteers are traditionally concerned with kinetics and tolerability, but useful information may also be obtained from biomarkers of clinical endpoints. A useful biomarker should meet the following requirements: a consistent response across studies and drugs; a clear response of the biomarker to a therapeutic dose; a dose-response relationship; a plausible relationship between biomarker, pharmacology and pathogenesis. In the current review… CONTINUE READING


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