Biomarkers for the Detection of Prenatal Alcohol Exposure: A Review

@article{Bager2017BiomarkersFT,
  title={Biomarkers for the Detection of Prenatal Alcohol Exposure: A Review},
  author={Heidi Bager and L. P. Christensen and S. Husby and L. Bjerregaard},
  journal={Alcoholism: Clinical and Experimental Research},
  year={2017},
  volume={41},
  pages={251–261}
}
Alcohol exposure during pregnancy can cause adverse effects to the fetus, because it interferes with fetal development, leading to later physical and mental impairment. The most common clinical tool to determine fetal alcohol exposure is maternal self-reporting. However, a more objective and useful method is based on the use of biomarkers in biological specimens alone or in combination with maternal self-reporting. This review reports on clinically relevant biomarkers for detection of prenatal… Expand
Screening for prenatal alcohol exposure and corresponding short-term neonatal outcomes.
TLDR
It is concluded that UC-PEth may be a valuable test for assessing PAE at birth and in identifying infants at risk for developing fetal alcohol spectrum disorder. Expand
An Integrative Screening Tool of Alcohol Exposure During Early Pregnancy: Combining of the CDT Biomarker with Green Page Questionnaire.
TLDR
Pregnant women with a CDT value >0.95% would be good candidates for the performance of the GP questionnaire during early pregnancy in order to detect potential high-risk pregnancy due to alcohol exposure. Expand
The association between prenatal alcohol consumption and preschool child stress system disturbance.
TLDR
The present study showed both the biological association of intrauterine alcohol exposure with the cortisol stress system, partly dose-dependent, and the functional association with emotional and behavioral symptoms. Expand
Ethylglucuronide in the urine as a marker of alcohol consumption during pregnancy: Comparison with four alcohol screening questionnaires.
TLDR
Clinical evidence is provided that the diagnosis of maternal alcohol consumption during pregnancy only based on indirect methods, such as questionnaires and food diary, may significantly underestimate alcohol use. Expand
Drug exposure during pregnancy: analytical methods and toxicological findings.
TLDR
The most recent analytical methods for quantifying drugs of abuse, tobacco, alcohol and psychotropic drugs in maternal, newborn and maternal-fetal unit biological samples by gas and liquid chromatography coupled to mass spectrometry are reviewed. Expand
The Early Developmental Outcomes of Prenatal Alcohol Exposure: A Review
TLDR
The outcomes related to lower levels of prenatal alcohol exposure as well as outcomes in specific developmental domains, are poorly understood and further research should aim to clarify the more subtle or less easily measurable manifestations of prenatalalcohol exposure on early development. Expand
Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview
TLDR
A wide range of phenotypic features are analyzed to identify fetal alcohol spectrum disorder phenotypes in murine models, exploring facial dysmorphology, neurodevelopmental deficits, and growth restriction, as well as the methodologies used to evaluate behavioral and anatomical alterations produced by prenatal alcohol exposure in rodents. Expand
The Placenta as a Target for Alcohol During Pregnancy: The Close Relation with IGFs Signaling Pathway.
TLDR
This review tries to examine the current knowledge and gaps in existing understanding of the ethanol effects in insulin/IGFs signaling pathway, which can explain the mechanism to elucidate the adverse actions of ethanol in the maternal-fetal interface of mammals. Expand
Fetus morphology changes by second‐trimester ultrasound in pregnant women drinking alcohol
TLDR
Clinical evidence is provided that the diagnosis of maternal alcohol consumption during pregnancy by urine EtG may disclose FASD‐related damage in the fetus. Expand
Diagnosis of Fetal Alcohol Spectrum Disorders (FASDs): Guidelines of Interdisciplinary Group of Polish Professionals
TLDR
National guidelines for diagnosis of fetal alcohol spectrum disorders in Poland may improve the quality and standardization of FASD diagnosis, but their practical utility has to be monitored. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 87 REFERENCES
Determination of maternal-fetal biomarkers of prenatal exposure to ethanol: a review.
TLDR
Bioanalytical procedures for the determination of markers of ethanol consumption during pregnancy and related prenatal exposure are reviewed and clinical toxicological applications of these procedures are presented and discussed. Expand
Determination of direct alcohol markers: a review
TLDR
The objective of this study is to review published studies that measure fatty-acid ethyl esters (FAEE), ethyl glucuronide (EtG), and phosphatidylethanol (PEth) in alternative biological matrices, focusing on the extraction and detection methods and full analytical conditions used. Expand
Ethyl linoleate in meconium: a biomarker for prenatal ethanol exposure.
TLDR
The presence of ethyl linoleate in meconium is the first reported biological marker for maternal ethanol use during pregnancy, and further validation of this marker will permit identification and intervention of at-risk infants. Expand
Prenatal alcohol exposure and its repercussion on newborns.
TLDR
As expected, many screening devices do not accurately capture use during pregnancy and supplemental methods such as meconium analysis of biomarkers of chronic alcohol consumption may be warranted. Expand
Ethylglucuronide in maternal hair as a biomarker of prenatal alcohol exposure.
TLDR
Data suggest that hEtG alone is not a sufficiently sensitive or specific biomarker to be used separately for the identification of PAE, but might be useful in a battery along with other maternal biomarkers. Expand
Hair Analysis of Fatty Acid Ethyl Esters in the Detection of Excessive Drinking in the Context of Fetal Alcohol Spectrum Disorders
TLDR
The high rate of positive FAEE results demonstrates that the FAEE hair test corroborates the clinical suspicion of alcohol use in parents of children at risk for FASD, and suggests that FAEEhair analysis may be a powerful tool in detecting excessive alcohol Use in the perinatal period. Expand
Validation of a new biomarker of fetal exposure to alcohol.
TLDR
Ethyl oleate concentration in meconium assayed by GC/MS/MS provides a highly sensitive and specific indicator of maternal alcohol use during pregnancy. Expand
The validity of phosphatidylethanol in dried blood spots of newborns for the identification of prenatal alcohol exposure.
TLDR
Newborn PEth-DBS is a highly specific biomarker and can facilitate accurate detection of PAE in conjunction with other biomarkers and could facilitate integration with routine newborn screening. Expand
The feasibility and cost of neonatal screening for prenatal alcohol exposure by measuring phosphatidylethanol in dried blood spots.
TLDR
Results indicate that screening for PAE in DBS cards is a feasible procedure and that a majority of infants have enough blood after the routine heel prick to fill an additional card, and that screening by PEth analysis from DBS Cards is cost-efficient. Expand
Fetal Exposure to Alcohol as Evidenced by Fatty Acid Ethyl Esters in Meconium in the Absence of Maternal Drinking History in Pregnancy
TLDR
Significantly elevated levels of FAEE above the baseline and the presence of multiple FAEE species in meconium are exclusive to neonates who have likely been exposed to excessive amounts of alcohol in utero, which could facilitate earlier diagnosis and intervention for less apparent forms of alcohol-related disabilities. Expand
...
1
2
3
4
5
...