Biomarkers for the 21st century: listening to the microbiome.
@article{Dietert2015BiomarkersFT,
title={Biomarkers for the 21st century: listening to the microbiome.},
author={Rodney Dietert and Ellen Kovner Silbergeld},
journal={Toxicological sciences : an official journal of the Society of Toxicology},
year={2015},
volume={144 2},
pages={
208-16
}
}The field of environmental research has benefited greatly from the concept of biomarkers, which originally expanded our thinking by opening the "black box" between environmental exposures and manifestations of disease and dysfunction in exposed populations, as laid out in a highly influential article published in 1987 by an expert committee convened by the National Research Council. Advances in biomedical research now challenge us to revise this concept to include the microbiome as a critical…
65 Citations
The Gut Microbiome and Xenobiotics: Identifying Knowledge Gaps.
- Medicine, BiologyToxicological sciences : an official journal of the Society of Toxicology
- 2020
A series of key recommendations were formulated to focus efforts to further understand host-microbiome interactions and the consequences of exposure to xenobiotics as well as identifying biomarkers of microbiome-associated disease and toxicity.
Gut microbiome metagenomics to understand how xenobiotics impact human health
- BiologyCurrent Opinion in Toxicology
- 2018
Microbiota and Dose Response: Evolving Paradigm of Health Triangle.
- Biology, MedicineRisk analysis : an official publication of the Society for Risk Analysis
- 2018
SRA Dose-Response and Microbial Risk Analysis Specialty Groups jointly sponsored symposia that addressed the intersections between the "microbiome revolution" and dose response, and a proposed new framework, the Health Triangle, may replace the old paradigm based on the Disease Triangle.
Integrating Microbiome Network: Establishing Linkages Between Plants, Microbes and Human Health
- Biology
- 2019
This review primarily focused on the advances and challenges in microbiome research at the interface of plant and human, and role of microbiome at different compartments of the body’s ecosystems along with their correlation to health and diseases.
Microbiome First Medicine in Health and Safety
- Medicine, Biology
- 2021
This paper presents microbiome-human physiology from the view of systems biology regulation and details the ongoing NCD epidemic including the role of existing drugs and other factors that damage the human microbiome.
Microbiome First Medicine in Health and Safety
- Medicine, BiologyBiomedicines
- 2021
This paper presents microbiome-human physiology from the view of systems biology regulation and details the ongoing NCD epidemic including the role of existing drugs and other factors that damage the human microbiome.
Small Molecule Modulation of Microbiome Ecosystem: A Systems Pharmacology Perspective
- Biology
- 2020
A disease-centric signed microbe-microbe interaction network which accurately predicts the pathogenic or commensal effect of microbe on human health is built which may open a new avenue for the small molecule drug discovery of microbiome.
Do Interactions Between Environmental Chemicals and the Human Microbiome Need to Be Considered in Risk Assessments?
- BiologyRisk analysis : an official publication of the Society for Risk Analysis
- 2019
It is suggested that failure to consider the possible roles of the microbiome could lead to significant error in risk assessment results and to urge the risk assessment community to begin considering and influencing how results from microbiome-related research could be incorporated into chemical risk assessments.
The current state and future direction of DoD gut microbiome research: a summary of the first DoD gut microbiome informational meeting
- Engineering, MedicineStandards in Genomic Sciences
- 2018
The 1st DoD Gut Microbiome Informational Meeting created a foundation for a coordinated gut microbiome and nutrition research program aligning key DoD partners in the area of microbiome research.
Microbiota dysbiosis: a new piece in the understanding of the carcinogenesis puzzle.
- BiologyJournal of medical microbiology
- 2016
The mechanisms described for pancreatic, lung, colorectal cancer, oral squamous cell carcinoma and hepatocellular carcinoma are analysed and the impact of the current knowledge about the effects of the microbiota on carcinogenesis is analyzed.
References
SHOWING 1-10 OF 55 REFERENCES
The human gut microbiota: a dynamic interplay with the host from birth to senescence settled during childhood
- BiologyPediatric Research
- 2014
The microbiota “organ” is the central bioreactor of the gastrointestinal tract, populated by a total of 1014 bacteria and characterized by a genomic content (microbiome), which represents more than…
Insights on the human microbiome and its xenobiotic metabolism: what is known about its effects on human physiology?
- Biology, MedicineExpert opinion on drug metabolism & toxicology
- 2015
This review provides an overview of the host–microbiome relationship in light of bacterial (xenobiotic) metabolism, community dynamics, entero-endocrine crosstalk, dysbiosis and potential therapeutic targets and highlights the need for a systematic analysis of the microbiome’s potential for substance toxification.
The microbiome in early life: self-completion and microbiota protection as health priorities.
- Biology, MedicineBirth defects research. Part B, Developmental and reproductive toxicology
- 2014
Basic features of management of the microbiome to facilitate self-completion, protection of the microbiota from environmental hazards, and the benefits of using a superorganism focus for health management beginning with pregnancy and extending throughout childhood and adult life are considered.
A framework for human microbiome research
- BiologyNature
- 2012
Resources from a population of 242 healthy adults sampled at 15 or 18 body sites up to three times are presented, which have generated 5,177 microbial taxonomic profiles from 16S ribosomal RNA genes and over 3.5 terabases of metagenomic sequence so far.
The Completed Self: An Immunological View of the Human-Microbiome Superorganism and Risk of Chronic Diseases
- MedicineEntropy
- 2012
This review discusses an immunological-driven sign termed the Completed Self, which is related to a holistic determination of health vs. disease, and discusses how these three events can combine to determine whether the human superorganism is able to adequately and completely form during early childhood.
The Intestinal Microbiome in Early Life: Health and Disease
- Biology, MedicineFront. Immunol.
- 2014
A greater understanding of how the early-life gut microbiota impacts the authors' immune development could potentially lead to novel microbial-derived therapies that target disease prevention at an early age.
Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation.
- BiologyChemical research in toxicology
- 2013
Data clearly illustrated that gut microbiome phenotypes significantly affected arsenic metabolic reactions, including reduction, methylation, and thiolation, which improve understanding of how infectious diseases and environmental exposure interact and may also provide novel insight regarding the gut microbiome composition as a new risk factor of individual susceptibility to environmental chemicals.
Programming of Host Metabolism by the Gut Microbiota
- Biology, MedicineAnnals of Nutrition and Metabolism
- 2011
The human gut harbors a vast ensemble of bacteria that has co-evolved with the human host and performs several important functions that affect the authors' physiology and metabolism, and reprogramming the gut microbiota in early life may have beneficial effects on host metabolism later in life.
A Taxonomic Signature of Obesity in the Microbiome? Getting to the Guts of the Matter
- Biology, MedicinePloS one
- 2014
There is no simple taxonomic signature of obesity in the microbiota of the human gut, as confirmed in publicly available data from the Human Microbiome Project and MetaHIT.
Host Genetics and Environmental Factors Regulate Ecological Succession of the Mouse Colon Tissue-Associated Microbiota
- Biology, MedicinePloS one
- 2012
The association of Nod2 genotype (and other host polymorphisms) and environmental factors likely combine to influence the ecological succession of the tissue-associated microflora accounting in part for their association with the pathogenesis of inflammatory bowel diseases.



