Biomarkers for prediction of TNFalpha blockers response in rheumatoid arthritis.


Tumor necrosis factor alpha (TNFalpha) is a pro-inflammatory cytokine that plays pivotal roles in regulating the inflammatory response in rheumatoid arthritis (RA). Intensive studies on TNFalpha-driven inflammation processes have led to the development of TNFalpha blockers for RA treatment. However, response to these therapies is heterogeneous with roughly… (More)
DOI: 10.1016/j.jbspin.2010.02.026