Biomarkers for Clinical and Incipient Tuberculosis: Performance in a TB-Endemic Country

Abstract

BACKGROUND Simple biomarkers are required to identify TB in both HIV(-)TB(+) and HIV(+)TB(+) patients. Earlier studies have identified the M. tuberculosis Malate Synthase (MS) and MPT51 as immunodominant antigens in TB patients. One goal of these investigations was to evaluate the sensitivity and specificity of anti-MS and -MPT51 antibodies as biomarkers… (More)
DOI: 10.1371/journal.pone.0002071

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