Biomarkers as surrogate endpoints in cancer trials.

  title={Biomarkers as surrogate endpoints in cancer trials.},
  author={Barbara K. Dunn and Esther G Akpa},
  journal={Seminars in oncology nursing},
  volume={28 2},
OBJECTIVES To define and discuss surrogate endpoint biomarkers, which are used in therapeutic trials as a substitute for the clinically meaningful "true" endpoint; and hence, may be used in answering cancer prevention questions in clinical trials evaluating drug/nutrient interventions for a number of common cancer sites. DATA SOURCES Literature, research articles. CONCLUSION Surrogate endpoint biomarkers offer greater efficiency in clinical studies because they may allow for the generation… CONTINUE READING

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