Biomarkers as predictors for conversion from mild cognitive impairment to Alzheimer-type dementia: implications for trial design.

@article{Rossum2010BiomarkersAP,
  title={Biomarkers as predictors for conversion from mild cognitive impairment to Alzheimer-type dementia: implications for trial design.},
  author={Ineke A van Rossum and Stephanie J. B. Vos and Ron L.H. Handels and Pieter Jelle Visser},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={20 3},
  pages={881-91}
}
Disease modifying drugs for Alzheimer's disease (AD) are likely to be most effective when given in non-demented subjects. In this review we summarized biomarkers in cerebrospinal fluid (CSF) and blood that can predict AD-type dementia in subjects with mild cognitive impairment (MCI). In addition, we investigated whether these markers could reduce sample size and costs if used to select subjects for trials on the prevention of AD in subjects with MCI. A meta-analysis of markers that had been… CONTINUE READING

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