Biomarkers: Portents of malignancy

  title={Biomarkers: Portents of malignancy},
  author={Vicki Brower},
  • V. Brower
  • Published 24 March 2011
  • Medicine
  • Nature
Being able to determine an individual's chances of developing cancer will greatly improve risk management strategies and recruitment to clinical trials. 

The role of biomarkers to detect progression of diseases

A biomarker is a substance isolated from human fluids which is known as the substances to indicate the presence or intensity of a particular disease condition.

Ovarian cancer screening and peritoneal carcinomatosis: standards, ‘omics’ and miRNAs for personalized management

The advances and challenges of ‘-omics’-based early-detection biomarkers, hyperthermic intraperitoneal chemotherapy (HIPEC) or neoadjuvant treatment in combination with standard cytoreductive surgery for the treatment of advanced disease and the exciting perspectives of miRNAs for a new generation of biomarkers and drugs are discussed.

Prognostic value of LIPC in non-small cell lung carcinoma

It is reported that the intratumoral levels of LIPC, as assessed by immunohistochemistry in two independent cohorts of NSCLC patients, positively correlate with disease outcome and appear to have an independent prognostic value (and perhaps a predictive potential) in the setting ofNSCLC.

Molecular biomarkers of DNA damage in diffuse large-cell lymphoma—a review

This investigation revealed a connection between almost all biomarkers, which are based on methods such as indirect immunofluorescence, fluorescence in-situ hybridization or immunohistochemistry, and the international prognostic index, based on clinical and basic laboratory features, remains the best risk predictor.

Biomarkers in psoriasis and psoriatic arthritis

A review of the different classes of possible biomarkers explored in psoriasis and PsA so far is summarised and novel strategies for biomarker discovery are discussed.

Predicting Suicidal Behavior: Are We Really that Far Along? Comment on “Discovery and Validation of Blood Biomarkers for Suicidality”

A recent publication focused on biomarkers of future suicidal behaviors identifies several genes expressed in high-risk states among four samples. We discuss the implications of this study as well as

Mass spectrometry-based intraoperative tumor diagnostics

The latest technical innovations for a more accurate tumor margin localization based on mass spectrometry are discussed, focusing on the intelligent knife, desorption electrospray ionization, picosecond infrared laser and MasSpec pen.

An overview of the significance of troponin in acute myocardial infarction

This review summarizes the start of biomarker research for AMI until the discovery of Troponin, emphasizes troponin’s usage today and provides possible ideas for future enhancement.



Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.

  • J. QiuG. Choi S. Hanash
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2008
Findings suggest potential utility of an approach to diagnosis of lung cancer before onset of symptoms that includes screening for autoantibodies to defined antigens.

Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development

D deregulation of the PI3K pathway in the bronchial airway epithelium of smokers is an early, measurable, and reversible event in the development of lung cancer and that genomic profiling of these relatively accessible airway cells may enable personalized approaches to chemoprevention and therapy.

Cancer biomarkers: can we turn recent failures into success?

  • E. Diamandis
  • Biology, Medicine
    Journal of the National Cancer Institute
  • 2010
In this commentary, a plethora of parameters before sampleAnalysis, during sample analysis, and after sample analysis that can complicate biomarker discovery and validation and lead to "false discovery" are discussed.

Reduced repair of the oxidative 8-oxoguanine DNA damage and risk of head and neck cancer.

It is reported that OGG activity in peripheral blood mononuclear cells from 37 cases with squamous cell carcinoma of the head and neck (SCCHN) was significantly lower than in 93 control subjects, frequency matched for age and gender.

Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium.

The findings suggest that nasal epithelial gene expression may serve as a relatively noninvasive surrogate to measure physiological responses to cigarette smoke and/or other inhaled exposures in large-scale epidemiological studies.

A Phase I Study of myo-Inositol for Lung Cancer Chemoprevention

Myo-Inositol in a daily dose of 18 g p.o. for 3 months is safe and well tolerated and the potential chemopreventive effect as well as other health benefits such as reduction in blood pressure should be investigated further.