Biomarkers: Application of intravascular ultrasound in anti-atherosclerotic drug development

  title={Biomarkers: Application of intravascular ultrasound in anti-atherosclerotic drug development},
  author={Stephen J Nicholls and Ilke Sipahi and Paul Schoenhagen and Tim D Crowe and Emin Murat Tuzcu and Steven Evan Nissen},
  journal={Nature Reviews Drug Discovery},
The background use of a number of established therapies presents a key challenge for the development of novel anti-atherosclerotic agents: how to predict potential efficacy before the completion of long-term trials with endpoints such as mortality. This challenge has stimulated the search to develop intermediate measures of efficacy. Recent advances now allow intravascular ultrasound (IVUS) to provide an accurate assessment of atheroma accumulation within the arterial wall. Here we describe how… CONTINUE READING
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