Biomarker validation of a decline in semantic processing in preclinical Alzheimer's disease.

@article{Papp2016BiomarkerVO,
  title={Biomarker validation of a decline in semantic processing in preclinical Alzheimer's disease.},
  author={Kathryn V. Papp and Elizabeth C. Mormino and Rebecca E. Amariglio and Catherine E. Munro and Alex S. Dagley and Aaron P. Schultz and Keith A. Johnson and Reisa A. Sperling and Dorene M. Rentz},
  journal={Neuropsychology},
  year={2016},
  volume={30 5},
  pages={
          624-30
        }
}
OBJECTIVE Differentially worse performance on category versus letter fluency suggests greater semantic versus retrieval difficulties. This discrepancy, combined with reduced episodic memory, has widespread clinical utility in diagnosing Alzheimer's disease (AD). Our objective was to investigate whether changes in semantic processing, as measured by the discrepancy between category and letter fluency, was detectable in preclinical AD: in clinically normal older adults with abnormal β-amyloid (A… CONTINUE READING

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