Biomarker utility of circulating tumor cells in metastatic cutaneous melanoma.

  title={Biomarker utility of circulating tumor cells in metastatic cutaneous melanoma.},
  author={Leila Khoja and Paul C. Lorigan and Cong Zhou and Matthew Lancashire and Jessica Booth and Jeff Cummings and Raffaele Califano and Glen Clack and Andrew K Hughes and Caroline Dive},
  journal={The Journal of investigative dermatology},
  volume={133 6},
The incidence of melanoma is increasing worldwide. Advances in targeted agents and immunotherapy have improved outcomes in metastatic disease, but biomarkers are required to optimize treatment. We determined the prevalence of circulating tumor cells (CTCs) and explored their utility as prognostic and pharmacodynamic biomarkers. A total of 101 patients with metastatic cutaneous melanoma were recruited prospectively. CTC number was determined using the CellSearch platform and melanoma kits in… CONTINUE READING


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Liquid Biopsy zur Überwachung von Melanompatienten.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG • 2018

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