Biomarker profile and genetic abnormalities in lobular carcinoma in situ

@article{Mohsin2004BiomarkerPA,
  title={Biomarker profile and genetic abnormalities in lobular carcinoma in situ},
  author={Syed K. Mohsin and Peter O’Connell and D. Craig. Allred and Arlene L. Libby},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={90},
  pages={249-256}
}
The predisposition of patients with lobular carcinoma in situ (LCIS) to develop invasive breast cancer (IBC) is well known. However, relatively little is known about the biologic characteristics, which may be involved in the development and progression of LCIS. This study evaluated 59 cases of LCIS (29 pure, 30 with synchronous IBC) for five biomarkers known to be important in IBC (ER, PgR, c-erbB-2, p53 and Ki-67 proliferation rate) by immunohistochemistry. A comprehensive analysis of loss-of… CONTINUE READING