Biomarker für Rauchen – Welche Cut-off-Werte sind anwendbar?

@article{Gruber2018BiomarkerFR,
  title={Biomarker f{\"u}r Rauchen – Welche Cut-off-Werte sind anwendbar?},
  author={Damian Gruber and Mac{\'e} M. Schuurmans},
  journal={Praxis},
  year={2018}
}
Zusammenfassung. Die Überprüfung des Raucherstatus mittels Biomarkern ist wichtig für Behandlungsentscheidungen von Patienten mit rauchbedingten Erkrankungen. Cotinin ist derzeit der beste Biomarker zur Dokumentation des Nikotinkonsums. Eine kostengünstige Alternative zur Bestimmung des Raucherstatus ist die Messung von Carboxyhämoglobin (CO-Hb) in der Ausatmungsluft. Der Hauptnachteil von CO-Hb ist die kurze Halbwertszeit. Der entsprechende Grenzwert für den aktiven Nikotinkonsum in der… 
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References

SHOWING 1-10 OF 27 REFERENCES

Cotinine as a biomarker of tobacco exposure: development of a HPLC method and comparison of matrices.

Results indicate that the urine normalization by creatinine or density is unnecessary and this method is considered reliable for determining cotinine in serum and plasma of smokers and in environmental tobacco smoke exposure.

Correction of urine cotinine concentrations for creatinine excretion: is it useful?

It is investigated how well spot urinary cotinine measurements correlated with concurrent serum concentrations in smokers, and whether normalizing for urine creatinine concentration improved the relationship.

Accelerated metabolism of nicotine and cotinine in pregnant smokers.

The data indicate that no downward dose adjustment needs to be made for nicotine replacement therapy during pregnancy, and higher than usual doses of nicotine may be necessary to optimize efficacy.

Carbon monoxide poisoning from waterpipe smoking: a retrospective cohort study

CO poisoning after waterpipe smoking may present in young adults with a wide variability of symptoms from none to unconsciousness, therefore diagnosis should be suspected even in the absence of symptoms.

Breath carbon monoxide as an indication of smoking habit.

Breath CO concentration provides an easy, noninvasive, and immediate way of assessing a patient's smoking status, and a reading > 6 ppm strongly suggests that an outpatient is a smoker.

Carbon monoxide in breath in relation to smoking and carboxyhaemoglobin levels.

Alveolar carbon monoxide measurement is thus a simple method of estimating whether a person is likely to be a smoker, indicating that COHb levels can be estimated reliably by measuring the concentration ofcarbon monoxide in breath.

Estimation of Cutoff Values of Cotinine in Urine and Saliva for Pregnant Women in Poland

The presented cut-off values for salivary and urinary cotinine ensure a categorization of the smoking status among pregnant women that is more accurate than self-reporting.

Human CYP2A6 Is Induced by Estrogen via Estrogen Receptor

It is demonstrated that CYP2A6 is directly induced by estrogen in an ERα-dependent manner, implying a biological role of CYP 2A6 in estrogen-responsive tissues, and can also explain clinical aspects of increased nicotine metabolism under estrogen-rich environments.

Importance of baseline cotinine plasma values in smoking cessation: results from a double-blind study with nicotine patch.

It is concluded that a higher success rate was obtained after one year in smokers with low baseline plasma cotinine values, which may be helpful in identifying smokers who could benefit from transdermal nicotine replacement.

Optimal serum cotinine levels for distinguishing cigarette smokers and nonsmokers within different racial/ethnic groups in the United States between 1999 and 2004.

Use of the currently accepted cutpoint of 14 ng/mL overestimates the number of nonsmokers in comparison with the proposed new overall cutpoint or the race/ethnicity-specific cutpoints of 1-6 ng/ mL.