Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.

@article{Siman2008BiomarkerEF,
  title={Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.},
  author={Robert A Siman and Victoria L. Roberts and Elizabeth A McNeil and Antony Dang and Joseph E. Bavaria and Sindhu Ramchandren and Michael McGarvey},
  journal={Brain research},
  year={2008},
  volume={1213},
  pages={1-11}
}
Previously, we identified 14-3-3 beta and zeta isoforms and proteolytic fragments of alpha-spectrin as proteins released from degenerating neurons that also rise markedly in cerebrospinal fluid (CSF) following experimental brain injury or ischemia in rodents, but these proteins have not been studied before as potential biomarkers for ischemic central nervous system injury in humans. Here we describe longitudinal analysis of these proteins along with the neuron-enriched hypophosphorylated… CONTINUE READING

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