Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.

  title={Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.},
  author={Mads Gr\onborg and Troels Z. Kristiansen and Akiko Iwahori and Rubens Chang and Raghunath Reddy and Norihiro Sato and Henrik Molina and Ole N\orregaard Jensen and Ralph H. Hruban and Michael G. Goggins and Anirban Maitra and Akhilesh Pandey},
  journal={Molecular & cellular proteomics : MCP},
  volume={5 1},
Quantitative proteomics can be used as a screening tool for identification of differentially expressed proteins as potential biomarkers for cancers. Candidate biomarkers from such studies can subsequently be tested using other techniques for use in early detection of cancers. Here we demonstrate the use of stable isotope labeling with amino acids in cell culture (SILAC) method to compare the secreted proteins (secretome) from pancreatic cancer-derived cells with that from non-neoplastic… CONTINUE READING
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Biomarker Discovery from the Pancreatic Cancer Secretome 168 Molecular & Cellular Proteomics 5.1 Comprehensive proteomic analysis of human pancreatic juice

  • M. Gronborg, J. Bunkenborg, +6 authors A. Pandey
  • J. Proteome Res
  • 2004
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