Bioluminescent Imaging and Histopathologic Characterization of WEEV Neuroinvasion in Outbred CD-1 Mice

@inproceedings{Phillips2013BioluminescentIA,
  title={Bioluminescent Imaging and Histopathologic Characterization of WEEV Neuroinvasion in Outbred CD-1 Mice},
  author={Aaron T. Phillips and Charles B. Stauft and Tawfik A Aboellail and Ann M. Toth and Donald L. Jarvis and Ann M Powers and Ken E Olson},
  booktitle={PloS one},
  year={2013}
}
Western equine encephalitis virus (WEEV; Alphavirus) is a mosquito-borne virus that can cause severe encephalitis in humans and equids. Previous studies have shown that intranasal infection of outbred CD-1 mice with the WEEV McMillan (McM) strain result in high mortality within 4 days of infection. Here in vivo and ex vivo bioluminescence (BLM) imaging was applied on mice intranasally infected with a recombinant McM virus expressing firefly luciferase (FLUC) to track viral neuroinvasion by FLUC… CONTINUE READING

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Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence.

Proceedings of the National Academy of Sciences of the United States of America • 2011
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