Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery.

  title={Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery.},
  author={Taraq M. Arain and Anna E Resconi and Michael J. Hickey and C Kendall Stover},
  journal={Antimicrobial agents and chemotherapy},
  volume={40 6},
Bioluminescence-based assays to indicate antimicrobial susceptibility have been developed and validated for recombinant strains of Mycobacterium tuberculosis, Mycobacterium bovis BCG, Mycobacterium avium, and Mycobacterium intracellulare expressing an integrated eukaryotic luciferase gene. MICs determined with these bioluminescence assays for several antimycobacterial agents, including isoniazid, ethambutol, rifampin, amikacin, streptomycin, ciprofloxacin, and clarithromycin, compared favorably… CONTINUE READING
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