Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy.

@article{Dinca2007BioluminescenceMO,
  title={Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy.},
  author={Eduard B. Dinca and Jann N. Sarkaria and Mark A Schroeder and Brett L. Carlson and Ramona V. Voicu and Nalin Gupta and Mitchel S. Berger and C. David James},
  journal={Journal of neurosurgery},
  year={2007},
  volume={107 3},
  pages={610-6}
}
OBJECT Bioluminescence imaging (BLI) offers a rapid and accurate means for longitudinal study of tumor cell growth and response to therapy in rodent models. Because this technology has only recently come into use in the field of small animal imaging, applications in this area have been limited. In the current study we have applied BLI to the analysis of clinically relevant issues involving use of the DNA methylating agent temozolomide (TMZ) in a mouse model. METHODS An invasive glioblastoma… CONTINUE READING