Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex.

@article{Shavkunov2012BioluminescenceMF,
  title={Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex.},
  author={Alexander S. Shavkunov and Neli E Panova and Anesh Prasai and Ron Veselenak and Nigel Bourne and Svetla Stoilova-McPhie and Fernanda Laezza},
  journal={Assay and drug development technologies},
  year={2012},
  volume={10 2},
  pages={148-60}
}
Protein-protein interactions are critical molecular determinants of ion channel function and emerging targets for pharmacological interventions. Yet, current methodologies for the rapid detection of ion channel macromolecular complexes are still lacking. In this study we have adapted a split-luciferase complementation assay (LCA) for detecting the assembly of the voltage-gated Na+ (Nav) channel C-tail and the intracellular fibroblast growth factor 14 (FGF14), a functionally relevant component… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
17 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…