Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic model1

@article{Chewning2009BioluminescencebasedVO,
  title={Bioluminescence-based visualization of CD4 T cell dynamics using a T lineage-specific luciferase transgenic model1},
  author={Joseph H. Chewning and Kari J Dugger and Tandra R. Chaudhuri and Kurt R. Zinn and Casey T Weaver},
  journal={BMC Immunology},
  year={2009},
  volume={10},
  pages={44 - 44}
}
Rapid clonal expansion of T cells occurs in response to antigenic challenges. The kinetics of the T cell response has previously been described using tissue-based studies performed at defined time points. Luciferase bioluminescence has recently been utilized for non-invasive analysis of in vivo biologic processes in real-time. We have created a novel transgenic mouse model (T-Lux) using a human CD2 mini-gene to direct luciferase expression specifically to the T cell compartment. T-Lux T cells… CONTINUE READING

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