Biology without walls: the novel endocrinology of bone.

  title={Biology without walls: the novel endocrinology of bone.},
  author={Gerard Karsenty and Franck Oury},
  journal={Annual review of physiology},
Classical studies of vertebrate physiology have usually been confined to a given organ or cell type. The use of mouse genetics has changed this approach and has rejuvenated the concept of a whole-body study of physiology. One physiological system that has been profoundly influenced by mouse genetics is skeletal physiology. Indeed, genetic approaches have identified several unexpected organs that affect bone physiology. These new links have begun to provide a plausible explanation for the… CONTINUE READING


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