Biology pH and the recycling of transferrin during receptor - mediated endocytosis ( endocytic vesicle / apotransferrin / transferrin receptor )

Abstract

At pH 5.4, apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0. Apotransferrin is quickly dissociated from its receptor when the pH is raised to 7.0. These and other results strongly support a simple model that explains the cycling of… (More)

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