Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes

  title={Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes},
  author={Fredrik Karpe and Katherine E. Pinnick},
  journal={Nature Reviews Endocrinology},
The distribution of adipose tissue in the body has wide-ranging and reproducible associations with health and disease. Accumulation of adipose tissue in the upper body (abdominal obesity) is associated with the development of cardiovascular disease, insulin resistance, type 2 diabetes mellitus and even all-cause mortality. Conversely, accumulation of fat in the lower body (gluteofemoral obesity) shows opposite associations with cardiovascular disease and type 2 diabetes mellitus when adjusted… 
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