Biology of transforming growth factor beta in hepatocarcinogenesis.

  title={Biology of transforming growth factor beta in hepatocarcinogenesis.},
  author={Walter Rossmanith and Rolf Schulte-Hermann},
  journal={Microscopy research and technique},
  volume={52 4},
TGF-beta is an important factor in the regulation of liver growth. It is an inhibitor of hepatocyte DNA synthesis and may induce active cell death, e.g., to remove excessive tissue mass. Studies using transgenic mice suggest that expression in the resting liver has to be well balanced; either under- or overexpression appear to cause an increased turnover of hepatocytes and to predispose to hepatocarcinogenesis. TGF-beta overexpression is frequently observed in human hepatocellular carcinomas… CONTINUE READING

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