Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology

@article{Dutto2014BiologyOT,
  title={Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology},
  author={Ilaria Dutto and Micol Tillhon and Ornella Cazzalini and Lucia Anna Stivala and Ennio Prosperi},
  journal={Archives of Toxicology},
  year={2014},
  volume={89},
  pages={155-178}
}
The cell cycle inhibitor p21CDKN1A is a protein playing multiple roles not only in the DNA damage response, but also in many cellular processes during unperturbed cell growth. The main, well-known function of p21 is to arrest cell cycle progression by inhibiting the activity of cyclin-dependent kinases. In addition, p21 is involved in the regulation of transcription, apoptosis, DNA repair, as well as cell motility. However, p21 appears to a have a dual-face behavior because, in addition to its… CONTINUE READING

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