Biology of the bone marrow microenvironment and myelodysplastic syndromes.


Myelodysplastic syndromes (MDS) are characterized by cytopenias resulting from ineffective hematopoiesis with a predisposition to transform to acute myeloid leukemia (AML). Recent evidence suggests that the hematopoietic stem cell microenvironment contributes to the pathogenesis of MDS. Inflammation and hypoxia within the bone marrow are key regulators of… (More)
DOI: 10.1016/j.ymgme.2015.07.004