Biology of the blood–nerve barrier and its alteration in immune mediated neuropathies

@article{Kanda2012BiologyOT,
  title={Biology of the blood–nerve barrier and its alteration in immune mediated neuropathies},
  author={Takashi Kanda},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={2012},
  volume={84},
  pages={208 - 212}
}
  • T. Kanda
  • Published 2012
  • Biology, Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
The blood–nerve barrier (BNB) is a dynamic and competent interface between the endoneurial microenvironment and the surrounding extracellular space or blood. It is localised at the innermost layer of the multilayered ensheathing perineurium and endoneurial microvessels, and is the key structure that controls the internal milieu of the peripheral nerve parenchyma. Since the endoneurial BNB is the point of entry for pathogenic T cells and various soluble factors, including cytokines, chemokines… Expand
Breakdown of blood‐nerve barrier in immune‐mediated neuropathy
TLDR
Insight regarding the pathology and pathophysiology of BNB breakdown in the setting of the immune‐mediated neuropathy is highlighted and how this knowledge can be used to develop novel therapeutic strategies for treating immune‐ mediated neuropathies by manipulating the BNB is discussed. Expand
Biology of the human blood-nerve barrier in health and disease
  • E. Ubogu
  • Medicine
  • Experimental Neurology
  • 2020
TLDR
Early advancements have the potential to not only increase the understanding of how the BNB works and adapts or fails to adapt to varying insult, but provide insights relevant to pathogenic leukocyte trafficking, with translational potential and specific therapeutic application for chronic peripheral neuropathies and neuropathic pain. Expand
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TLDR
Emerging experimental advancements targeting the endoneurial microvasculature for the therapeutic management of immune-mediated inflammatory peripheral neuropathies, including the AIDP variant of Guillain-Barré syndrome, are discussed. Expand
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Peripheral nerves and nerve roots comprise of three structural compartments: the outer epineurium consisting of longitudinal arrays of collagen fibers responsible for structural integrity and theExpand
Impact of Inflammation on the Blood-Neural Barrier and Blood-Nerve Interface: From Review to Therapeutic Preview.
  • S. Skaper
  • Biology, Medicine
  • International review of neurobiology
  • 2017
TLDR
This review will discuss the pathobiology of neuroinflammation with emphasis on mast cells and microglia, their roles in BBB health, and novel therapeutic opportunities, including nanoscale delivery for targeting these immune cells with a view to maintain the BBB. Expand
[Blood-nerve barrier and peripheral nerve regeneration].
  • T. Kanda
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  • 2013
Blood-nerve barrier (BNB) restricts the movement of soluble mediators and leukocytes from the blood contents to the peripheral nervous system (PNS) parenchyma and thus maintains the endoneurialExpand
The pathogenic relevance of αM-integrin in Guillain–Barré syndrome
The molecular determinants and mechanisms involved in leukocyte trafficking across the blood–nerve barrier (BNB) in the acute inflammatory demyelinating polyradiculoneuropathy (AIDP) variant ofExpand
The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications
TLDR
The main mechanisms involved in the impairment of endothelial cells in specific diseases associated with peripheral nerve damage, such as diabetic neuropathy, erectile dysfunction and inflammation of the sciatic nerve are highlighted. Expand
Quantitative and Microstructural Changes of the Blood-Nerve Barrier in Peripheral Neuropathy
TLDR
Examination of changes in expression and microstructural localization of two key tight junction proteins, claudin-1 and the cytoplasmic anchoring ZO-1, in the sciatic nerve of mice subjected to chronic constriction injury provides evidence that peripheral neuropathy is associated with decrease in relevant TJPs but also exhibits alterations in TJP arrangement and loss in barrier tightness. Expand
Blood–Nerve Barrier (BNB) Pathology in Diabetic Peripheral Neuropathy and In Vitro Human BNB Model
TLDR
The pathologic evidence of the pathology of DPN in terms of BNB disruption is reviewed, the current in vitro BNB models are introduced, and immortalized cell lines originating from the human BNB are established. Expand
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TLDR
Results suggest that PnMECs constituting the bulk of BNB have a highly specialized characteristic resembling the endothelial cells forming BBB. Expand
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TLDR
A greater knowledge of the dynamic nature of tight junctions and the factors that induce and/or modulate these key elements of the BNI will increase the understanding of peripheral nerve disorders as well as stimulate the development of therapeutic strategies to treat these disorders. Expand
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TLDR
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TLDR
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Investigation of the characteristics of peripheral nerve pericytes may provide novel strategies for modifying BNB functions and promoting peripheral nerve regeneration, because the BNB does not contain cells equivalent to astrocytes which regulate the BBB function. Expand
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TLDR
The downregulation of claudin-5 and altered localisation of ZO-1 seen in CIDP specimens may indicate that BNB derangement occurs in inflammatory neuropathies and may suggest new treatments based on properties of the BNB. Expand
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