Biology of insulin-like growth factors in development.

  title={Biology of insulin-like growth factors in development.},
  author={Jo{\"e}lle Dupont and Martin Holzenberger},
  journal={Birth defects research. Part C, Embryo today : reviews},
  volume={69 4},
Insulin-like growth factors (IGFs) provide essential signals for the control of embryonic and postnatal development in vertebrate species. In mammals, IGFs act through and are regulated by a system of receptors, binding proteins, and related proteases. In each of the many tissues dependent on this family of growth factors, this system generates a complex interaction specific to the tissue concerned. Studies carried out over the last decade, mostly with transgenic and gene knockout mouse models… CONTINUE READING

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