Biology of acute myeloid leukaemia.

  title={Biology of acute myeloid leukaemia.},
  author={H. A. Messner and James D Griffin},
  journal={Clinics in haematology},
  volume={15 3},
The assessment of clonogenic leukaemic precursors in cell culture has demonstrated considerable heterogeneity of patients with respect to their ability to give rise to leukaemic blast cell colonies. Specific growth patterns rather than the frequency of blast colonies, appear to be of prognostic value for the clinical outcome. In particular, blast cells with high self-renewal ability were associated with poor prognosis. A similar degree of heterogeneity among leukaemic blast cell populations can… CONTINUE READING