Biology of Microglia in the Developing Brain.

@article{Kaur2017BiologyOM,
  title={Biology of Microglia in the Developing Brain.},
  author={Charanjit Kaur and Gurugirijha Rathnasamy and Eng Ang Ling},
  journal={Journal of neuropathology and experimental neurology},
  year={2017},
  volume={76 9},
  pages={
          736-753
        }
}
Microglia exist in different morphological forms in the developing brain. They show a small cell body with scanty cytoplasm with many branching processes in the grey matter of the developing brain. However, in the white matter such as the corpus callosum where the unmyelinated axons are loosely organized, they appear in an amoeboid form having a round cell body endowed with copious cytoplasm rich in organelles. The amoeboid cells eventually transform into ramified microglia in the second… 

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References

SHOWING 1-10 OF 291 REFERENCES
The Origin and Nature of Microglia
Origin of microglia
TLDR
The results derived from the normal and altered brain development as well as from experimental lesions tend to favour the view of the monocytic nature of microglia.
The importance of microglia in the development of the vasculature in the central nervous system
TLDR
This review discusses the origin of CNS microglia and their localization within the brain based on data obtained in mice, and reviews evidence supporting a functional role of thesemicroglia in developmental angiogenesis.
Heterogeneity of microglial and perivascular cell populations: Insights gained from the facial nucleus paradigm
TLDR
In vivo investigations of the phagocytic and immunophenotypic properties of microglial and perivascular cells during the retrograde reaction of facial motor neurons are continued using intraneural injections of fluorogold and ricin followed by lectin and immunostaining for microglia.
GENESIS OF MICROGLIA IN THE HUMAN BRAIN
TLDR
The origin and evolution of these cells were traced in a series of human embryos and it was possible to demonstrate that microglia cells are derived from mesenchymal cells and have no direct genetic relationship to astrocytes and oligodendroglia cells.
Colonisation of the developing human brain and spinal cord by microglia: a review
TLDR
The phenotype and functional characteristics of fetal microglia are outlined in this review, and the need for specific cellular interactions and targeting is greater within the central nervous system than in other tissues.
Morphological and Phagocytic Profile of Microglia in the Developing Rat Cerebellum1,2,3
TLDR
It is found that microglial morphology changed from amoeboid to ramified during the first 3 postnatal weeks in a region specific manner, which implicates microglia as an important cellular component of the developing cerebellum.
Histochemical study of the differentiation of microglial cells in the developing human cerebral hemispheres.
TLDR
It is suggested that at least some amoeboid cells are transformed into microglial cells via the stages of poorly ramifying microglian cells, and also that, in the human cerebral hemispheres, appearance of the microglia elements is closely related with vascularisation, especially in the early developmental stages.
...
1
2
3
4
5
...