Biology of IgE production: IgE cell differentiation and the memory of IgE responses.

@article{He2015BiologyOI,
  title={Biology of IgE production: IgE cell differentiation and the memory of IgE responses.},
  author={Jin-Shu He and Sriram Narayanan and Sharrada Subramaniam and Wen Qi Ho and Juan Jose Lafaille and Maria A Curotto de Lafaille},
  journal={Current topics in microbiology and immunology},
  year={2015},
  volume={388},
  pages={1-19}
}
The generation of long-lived plasma cells and memory B cells producing high-affinity antibodies depends on the maturation of B cell responses in germinal centers. These processes are essential for long-lasting antibody-mediated protection against infections. IgE antibodies are important for defense against parasites and toxins and can also mediate anti-tumor immunity. However, high-affinity IgE is also the main culprit responsible for the manifestations of allergic disease, including life… CONTINUE READING

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