Biology of IL-21 and the IL-21 receptor.

@article{Mehta2004BiologyOI,
  title={Biology of IL-21 and the IL-21 receptor.},
  author={Devangi S. Mehta and Andrea L. Wurster and M. J. Grusby},
  journal={Immunological reviews},
  year={2004},
  volume={202},
  pages={84-95}
}
Interleukin-21 (IL-21) is the newest member of the common gamma-chain family of cytokines, which includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15. Its private receptor, IL-21R, has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells. More… CONTINUE READING

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