Biology of Fibroblast Growth Factor 23: From Physiology to Pathology.

@article{Courbebaisse2018BiologyOF,
  title={Biology of Fibroblast Growth Factor 23: From Physiology to Pathology.},
  author={Marie Courbebaisse and Beate Lanske},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2018},
  volume={8 5}
}
Fibroblast growth factor (FGF)23 is a phosphaturic hormone produced by osteocytes and osteoblasts that binds to FGF receptors in the presence of the transmembrane protein αKlotho. FGF23 mainly targets the renal proximal tubule to inhibit calcitriol production and the expression of the sodium/phosphate cotransporters NaPi2a and NaPi2c, thus inhibiting renal phosphate reabsorption. FGF23 also acts on the parathyroid glands to inhibit parathyroid hormone synthesis and secretion. FGF23 regulation… CONTINUE READING