Biology and principles of periodontal wound healing/regeneration.

  title={Biology and principles of periodontal wound healing/regeneration.},
  author={Giuseppe Polimeni and Andreas V. Xiropaidis and Ulf M E Wikesj{\"o}},
  journal={Periodontology 2000},
The native periodontium includes cementum, a functionally oriented periodontal ligament, alveolar bone and gingiva. Pathologic and/or traumatic events may lead to the loss or damage of this anatomical structure. Since the 1970s, a number of procedures have been investigated in an attempt to restore such lost tissues. Numerous clinical trials have shown positive outcomes for various reconstructive surgical protocols. Reduced probing depths, clinical attachment gain, and radiographic bone fill… 

Healing after Periodontal Surgery - A Review

The basic principles of periodontal regeneration are discussed, to illustrate the factors that influence this process and to provide an overview of WH followingperiodontal surgical procedures.

A canine model for histometric evaluation of periodontal regeneration.

S surgically created preclinical models, particularly the one-wall intrabony periodontal defect model, are discussed for use in evaluation ofperiodontal regeneration.

A Review of Tissue Engineering for Periodontal Tissue Regeneration

  • E. Ward
  • Medicine, Biology
    Journal of veterinary dentistry
  • 2021
Tissue engineering has been proven to successfully regenerate lost periodontal tissues and this new possibility for treating veterinary patients is discussed, including scaffolds, signaling molecules, stem cells, and gene therapy.

Regenerative periodontal therapy.

An overview of the most important biologic events involved in periodontal wound healing/ regeneration is provided and on the criteria on how to select the appropriate regenerative material and surgical technique in order to optimize the clinical outcomes is provided.

Regenerative potential and healing dynamics of the periodontium: a critical-size supra-alveolar periodontal defect study.

A high degree of concordance and significant linear relationship was observed between cementum, PDL and bone regeneration indicating that their formation virtually occurred in parallel under optimal circumstances for periodontal wound healing/regeneration.

Methods of assessing periodontal tissues healing after periodontal therapy

This study aims to present the methods of clinical, radiographic, histological and cytological examination in the assessment of periodontal tissue healing afterperiodontal therapy to ensure an effective therapy.

Short communication: Stem Cells for Periodontal Tissue Regeneration

For decades, periodontists have sought to repair the damage from periodontitis and to achieve regeneration through a variety of non-surgical procedures and surgical procedures that include root surface conditioning, bone graft placement, guided tissue regeneration and the application of growth factors.

Periodontal tissue engineering and regeneration: current approaches and expanding opportunities.

Current regenerative procedures for periodontal healing and regeneration are summarized and their progress and difficulties in clinical practice are explored, with particular emphasis placed upon current challenges and future possibilities associated with tissue-engineering strategies inperiodontal regenerative medicine.



Periodontal repair in dogs. Healing patterns in large circumferential periodontal defects.

The range of healing responses indicates that a biological potential exists which makes this model useful for testing the effect of various root and wound conditioners in enhancing cementum formation on the root surface, increasing regeneration of alveolar bone and preventing aberrant healing events such as root resorption and ankylosis.

Periodontal repair in dogs: effect of wound stabilization on healing.

The results support the importance of wound stabilization in periodontal wound healing and development of biodegradable implant systems aimed at stabilizing and supporting the healing wound seems a desirable direction for future research in regenerativeperiodontal procedures.

Healing following implantation of periodontitis affected roots into bone tissue.

The results indicate that in addition to apical migration of junctional epithelium and regrowth of subgingival plaque, the type of cells which repopulate the wound area may jeopardize new connective tissue attachment.

New attachment following surgical treatment of human periodontal disease.

The hypothesis that new connective tissue attachment may form on a previously periodontitis involved root surface provided cells originating from the periodontal ligament are enabled to repopulate the root surface during healing is tested and the concept that theperiodontitis affected root surface is a major preventive factor for new attachment is invalid.

The regenerative potential of the periodontal ligament. An experimental study in the monkey.

The results of the experiment suggest that the periodontal ligament cells possess the ability to reestablish connective tissue attachment in the wound area adjacent to a root which has been surgically deprived of its periodontic ligament and cementum layer.

Histometric evaluation of periodontal surgery. II. Connective tissue attachment levels after four regenerative procedures.

The data revealed that healing following the four different regenerative procedures resulted in the reformation of an epithelial lining (long junctional epithelium) along the treated root surfaces, with no new connective tissue attachment.

Healing following implantation of periodontitis-affected roots into gingival connective tissue.

The results indicate that gingival connective tissue does not possess the ability to establish conditions which enable the formation of a new connectives attachment on a previously periodontitis involved root surface.

Repair of periodontal furcation defects in beagle dogs following reconstructive surgery including root surface demineralization with tetracycline hydrochloride and topical fibronectin application.

It was concluded that application of fibronectin to demineralized root surfaces did not enhance the amount of connective tissue repair and did not alter the pattern of root resorption and ankylosis.

Periodontal repair in surgically created intrabony defects in dogs: influence of the number of bone walls on healing response.

One- and 3-wall intrabony defects appear to be reproducible models to evaluate candidate technologies for periodontal regeneration in beagle dogs, and the results suggest that the number of bone walls is a critical factor determining treatment outcomes in intrabonesperiodontal defects.

Periodontal repair in dogs: a bioabsorbable calcium carbonate coral implant enhances space provision for alveolar bone regeneration in conjunction with guided tissue regeneration.

The coral implant significantly enhanced space provision for GTR while alveolar bone formation appeared to be enhanced by its use, and increased healing intervals are needed to fully understand the biologic value of the coral implant as an adjunct to GTR.