Biology and management of idiopathic myelofibrosis.

  title={Biology and management of idiopathic myelofibrosis.},
  author={Bruce D. Smith and Alison R. Moliterno},
  journal={Current opinion in oncology},
  volume={13 2},
Idiopathic myelofibrosis (IMF) is a hematopoietic stem cell disorder characterized by hypercellularity of the bone marrow with an increase in abnormal megakaryocytes, varying degrees of marrow fibrosis, and extramedullary hematopoiesis. The central lesion of the IMF stem cell is not known; however, the marrow fibrosis is a polyclonal reaction to… CONTINUE READING