Biology and insights into the role of cohesin protease separase in human malignancies.

@article{Zhang2017BiologyAI,
  title={Biology and insights into the role of cohesin protease separase in human malignancies.},
  author={Nenggang Zhang and Debananda Pati},
  journal={Biological reviews of the Cambridge Philosophical Society},
  year={2017},
  volume={92 4},
  pages={
          2070-2083
        }
}
Separase, an enzyme that resolves sister chromatid cohesion during the metaphase-to-anaphase transition, plays a pivotal role in chromosomal segregation and cell division. Separase protein, encoded by the extra spindle pole bodies like 1 (ESPL1) gene, is overexpressed in numerous human cancers including breast, bone, brain, and prostate. Separase is oncogenic, and its overexpression is sufficient to induce mammary tumours in mice. Either acute or chronic overexpression of separase in mouse… CONTINUE READING

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