Biology and genetics of oculocutaneous albinism and vitiligo - common pigmentation disorders in southern Africa.

@article{Manga2013BiologyAG,
  title={Biology and genetics of oculocutaneous albinism and vitiligo - common pigmentation disorders in southern Africa.},
  author={Prashiela Manga and Robyn Kerr and Mich{\'e}le Ramsay and Jennifer G. R. Kromberg},
  journal={South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde},
  year={2013},
  volume={103 12 Suppl 1},
  pages={984-8}
}
Pigmentation disorders span the genetic spectrum from single-gene autosomal recessive disorders such as oculocutaneous albinism (OCA), the autosomal dominant disorder piebaldism to X-linked ocular albinism and multifactorial vitiligo. OCA connotes a group of disorders that result in hypopigmented skin due to decreased melanin production in melanocytes and loss of visual acuity. There are four non-syndromic forms, OCA1-4, which are classified based on the gene that is mutated (tyrosinase, OCA2… CONTINUE READING
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