Biology and genetics of adult male germ cell tumors.

  title={Biology and genetics of adult male germ cell tumors.},
  author={Jane Houldsworth and James Korkola and George J. Bosl and Raju S. K. Chaganti},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={24 35},
Adult male germ cell tumors (GCTs) arise by transformation of totipotent germ cells. They have the unique potential to activate molecular pathways, in part mimicking those occurring during gametogenesis and normal human development, as evidenced by the array of histopathologies observed in vivo. Recent expression profiling studies of GCTs along with advances in embryonic stem-cell research have contributed to our understanding of the underlying biology of the disease. Gain of the short arm of… CONTINUE READING