Biology and clinical significance of the TEL/AML1 rearrangement.

  title={Biology and clinical significance of the TEL/AML1 rearrangement.},
  author={Arndt Borkhardt and Jochen Harbott and Fritz Lampert},
  journal={Current opinion in pediatrics},
  volume={11 1},
The accurate identification of chromosomal abnormalities in patients with leukemia is essential for diagnosis and treatment assignment. Recent technical improvements in the detection of such aberrations have demonstrated that the previously unrecognized chromosomal translocation t(12;21) is the most prevalent structural aberration in childhood acute lymphoblastic leukemia. Both genes involved, translocation ets like gene (or ETV6) on chromosome 12 and acute myeloid leukemia 1 gene (or CBF alpha… CONTINUE READING