Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer.

@article{Haq2011BiologyAC,
  title={Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer.},
  author={Rizwan Haq and David E Fisher},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 25},
  pages={3474-82}
}
Members of the micropthalmia (MiT) family of transcription factors (MITF, TFE3, TFEB, and TFEC) are physiologic regulators of cell growth, differentiation, and survival in several tissue types. Because their dysregulation can lead to melanoma, renal cell carcinoma, and some sarcomas, understanding why these genes are co-opted in carcinogenesis may be of general utility. Here we describe the structure of the MiT family of proteins, the ways in which they are aberrantly activated, and the… CONTINUE READING