Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus

@article{Gao2018BiologyAC,
  title={Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus},
  author={Ping Gao and Ji-han Xia and Csilla Sipeky and Xiao-Ming Dong and Gong-Hong Wei},
  journal={Cell},
  year={2018},
  volume={174},
  pages={576-589.e18}
}
Genome-wide association studies (GWAS) have identified rs11672691 at 19q13 associated with aggressive prostate cancer (PCa). Here, we independently confirmed the finding in a cohort of 2,738 PCa patients and discovered the biological mechanism underlying this association. We found an association of the aggressive PCa-associated allele G of rs11672691 with elevated transcript levels of two biologically plausible candidate genes, PCAT19 and CEACAM21, implicated in PCa cell growth and tumor… CONTINUE READING
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