Biology: Cell sex matters

  title={Biology: Cell sex matters},
  author={Elizabeth Pollitzer},
Male and female cells can behave differently — it is time that researchers, journals and funders took this seriously, says Elizabeth Pollitzer. 
It takes two to tango: including a female perspective in reproductive biology.
This edition of ICB includes a series of papers that focus on reproduction from the female perspective that use a question and answer format to leverage the diverse perspectives and voices involved with the symposium in an exploration of theoretical, cultural, pedagogical, and scientific issues related to the study of female biology.
I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?".
The title of this article suggests that sex is a universal truth, but in the experience of the authors of this Editorial Focus, this is rarely the case in scientific experiments, including in physiology, and especially cell physiology.
Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells
It is hypothesized that the donor sex of hADSCs is a variable influencing a wide range of stem cell biologic processes and should be considered in biologic research and stem cell therapy.
The Gender of Cell Lines Matters When Screening for Novel Anti-Cancer Drugs
The findings revealed that 79 out of 81 of the compounds consistently inflicted higher levels of toxicity towards male derived cells, emphasizing that there is indeed a gender-related difference in cell sensitivity to these anti-neoplastic agents.
Sexually-dimorphic targeting of functionally-related genes in COPD
The ensemble approach to network analysis is believed to provide a principled way to capture sex-specific regulatory relationships and could be applied to identify differences in gene regulatory patterns in a wide variety of diseases and contexts.
Let's Talk About Sex—Biological Sex Is Underreported in Biomaterial Studies
Sex as a biological variable is missing from an overwhelming majority of in vitro biomaterial studies and will require the biomaterials field to “talk about sex” by reporting cell sex more broadly.
Sex-specific eNOS activity and function in human endothelial cells
Sex-specific differences in the EC expression, activity, and function of eNOS are found and intrinsic sexual dimorphism of ECs should be further evaluated to achieve more effective and precise strategies for the prevention and therapy of diseases associated to an impaired endothelial function.
Sex and Gender Bias in Kidney Transplantation: 3D Bioprinting as a Challenge to Personalized Medicine
It is concluded that personalized techniques such as 3D bioprinting of kidneys alone do not mean that sex and gender bias does not happen and sex andGender considerations should be included into every step of developing and using 3D-bioprinted kidneys: in the choice of design, cells, biomaterials, and X-chromosome-activated cells.
Why gender is relevant to materials science and engineering
This paper shows that often the answer should be yes it is that the gender dimension in new materials research and engineering and especially in nano-materials applications is relevant to the project’s objectives.
Women have more potential to induce browning of perirenal adipose tissue than men
This work studied sex differences in BAT‐like properties of human perirenal adipose tissue and found that females have more active BAT or BAT‐ like WAT.


Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells
It is concluded that cells differ innately according to sex irrespective of their history of exposure to sex hormones, which may have consequences in the course of sexually dimorphic diseases and their therapy.
Exploring the Biological Contributions to Human Health: Does Sex Matter?
Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life.
Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers
It is shown that the metabolite profiles of males and females are significantly different and, furthermore, that specific genetic variants in metabolism-related genes depict sexual dimorphism.
Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway*
Gender stratification is supported in the evaluation of mechanisms and treatment of CNS disease, particularly those where glutathione may play a role in detoxification, such as Parkinson's disease, traumatic brain injury, and conditions producing cerebral ischemia, and may apply to non-CNS diseases as well.
Under‐representation of women in high‐impact published clinical cancer research
Adequate representation of women in research has been deemed essential and should be a priority for the next generation of scientists.
A role for cell sex in stem cell–mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency
It is shown here that cell sex is a variable that considerably influences MDSCs' regeneration abilities and should persuade researchers to report cell sex, which is a largely unexplored variable, and consider the implications of relying on cells of one sex.
If working with only one sex or gender, then specify that, and explain why.” 2 4 | N A T U R E | V O L 5 0 0 | 1 A U G U S T 2 0 1 3 COMMENT
  • J. Biol. Chem. 279,
  • 2004