Biology: Cell sex matters

  title={Biology: Cell sex matters},
  author={Elizabeth Pollitzer},
Male and female cells can behave differently — it is time that researchers, journals and funders took this seriously, says Elizabeth Pollitzer. 
It takes two to tango: including a female perspective in reproductive biology.
This edition of ICB includes a series of papers that focus on reproduction from the female perspective that use a question and answer format to leverage the diverse perspectives and voices involved with the symposium in an exploration of theoretical, cultural, pedagogical, and scientific issues related to the study of female biology. Expand
Taking into account the gender issue in cell death studies
The cell-sex-associated implication of RLIP76 in the maintenance of cell homeostasis, aimed at the development of a made-to-measure pharmacologic approach that, taking into account gender disparity, could provide new and successful therapeutic strategies, is described. Expand
Does cellular sex matter? Dimorphic transcriptional differences between female and male endothelial cells.
Female HUVEC showed a more pronounced transcriptional response to shear than did their male counterparts and a number of genes were regulated in the opposite direction between the two sexes by shear stress, underscore the importance for differentiation between male and female cells in cell culture experiments. Expand
I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?".
  • C. Fuller, P. Insel
  • Psychology, Medicine
  • American journal of physiology. Cell physiology
  • 2014
The title of this article suggests that sex is a universal truth, but in the experience of the authors of this Editorial Focus, this is rarely the case in scientific experiments, including in physiology, and especially cell physiology. Expand
Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells
It is hypothesized that the donor sex of hADSCs is a variable influencing a wide range of stem cell biologic processes and should be considered in biologic research and stem cell therapy. Expand
Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy.
The sex bias in eicosanoid biology possibly underlying the obvious sex disparities in inflammation is highlighted, stimulating scientists to take sex into account when studying the pathophysiology and pharmacotherapy of inflammatory diseases. Expand
The Gender of Cell Lines Matters When Screening for Novel Anti-Cancer Drugs
The findings revealed that 79 out of 81 of the compounds consistently inflicted higher levels of toxicity towards male derived cells, emphasizing that there is indeed a gender-related difference in cell sensitivity to these anti-neoplastic agents. Expand
Sexually-dimorphic targeting of functionally-related genes in COPD
The ensemble approach to network analysis is believed to provide a principled way to capture sex-specific regulatory relationships and could be applied to identify differences in gene regulatory patterns in a wide variety of diseases and contexts. Expand
Sex-specific eNOS activity and function in human endothelial cells
Sex-specific differences in the EC expression, activity, and function of eNOS are found and intrinsic sexual dimorphism of ECs should be further evaluated to achieve more effective and precise strategies for the prevention and therapy of diseases associated to an impaired endothelial function. Expand
Let's Talk About Sex-Biological Sex Is Underreported in Biomaterial Studies.
In analyzing research articles from seven prominent biomaterials journals, sex as a biological variable is missing from an overwhelming majority of in vitro biomaterial studies and this leads to a gap in the understanding of sex-specific cell-biomaterial interactions. Expand


Under‐representation of women in high‐impact published clinical cancer research
Adequate representation of women in research has been deemed essential and should be a priority for the next generation of scientists. Expand
Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells
  • C. Penaloza, Brian Estevez, +6 authors Z. Zakeri
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009
It is concluded that cells differ innately according to sex irrespective of their history of exposure to sex hormones, which may have consequences in the course of sexually dimorphic diseases and their therapy. Expand
Innate Gender-based Proclivity in Response to Cytotoxicity and Programmed Cell Death Pathway*
Gender stratification is supported in the evaluation of mechanisms and treatment of CNS disease, particularly those where glutathione may play a role in detoxification, such as Parkinson's disease, traumatic brain injury, and conditions producing cerebral ischemia, and may apply to non-CNS diseases as well. Expand
Exploring the Biological Contributions to Human Health: Does Sex Matter?
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or whyExpand
A role for cell sex in stem cell–mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency
It is shown here that cell sex is a variable that considerably influences MDSCs' regeneration abilities and should persuade researchers to report cell sex, which is a largely unexplored variable, and consider the implications of relying on cells of one sex. Expand
Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers
It is shown that the metabolite profiles of males and females are significantly different and, furthermore, that specific genetic variants in metabolism-related genes depict sexual dimorphism. Expand
Studying sex and gender differences in pain and analgesia: A consensus report
In September 2006, members of the Sex, Gender and Pain Special Interest Group of the International Association for the Study of Pain met to discuss the following: (1) what is known about sex andExpand
If working with only one sex or gender, then specify that, and explain why.” 2 4 | N A T U R E | V O L 5 0 0 | 1 A U G U S T 2 0 1 3 COMMENT
  • J. Biol. Chem. 279,
  • 2004