Biology: Cell sex matters

@article{Pollitzer2013BiologyCS,
  title={Biology: Cell sex matters},
  author={Elizabeth Pollitzer},
  journal={Nature},
  year={2013},
  volume={500},
  pages={23-24}
}
Male and female cells can behave differently — it is time that researchers, journals and funders took this seriously, says Elizabeth Pollitzer. 
It takes two to tango: including a female perspective in reproductive biology.
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This edition of ICB includes a series of papers that focus on reproduction from the female perspective that use a question and answer format to leverage the diverse perspectives and voices involved with the symposium in an exploration of theoretical, cultural, pedagogical, and scientific issues related to the study of female biology. Expand
Taking into account the gender issue in cell death studies
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The cell-sex-associated implication of RLIP76 in the maintenance of cell homeostasis, aimed at the development of a made-to-measure pharmacologic approach that, taking into account gender disparity, could provide new and successful therapeutic strategies, is described. Expand
Does cellular sex matter? Dimorphic transcriptional differences between female and male endothelial cells.
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I don't know the question, but sex is definitely the answer! Focus on "In pursuit of scientific excellence: sex matters" and "Do you know the sex of your cells?".
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  • Psychology, Medicine
  • American journal of physiology. Cell physiology
  • 2014
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The title of this article suggests that sex is a universal truth, but in the experience of the authors of this Editorial Focus, this is rarely the case in scientific experiments, including in physiology, and especially cell physiology. Expand
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It is hypothesized that the donor sex of hADSCs is a variable influencing a wide range of stem cell biologic processes and should be considered in biologic research and stem cell therapy. Expand
Sex-biased eicosanoid biology: Impact for sex differences in inflammation and consequences for pharmacotherapy.
TLDR
The sex bias in eicosanoid biology possibly underlying the obvious sex disparities in inflammation is highlighted, stimulating scientists to take sex into account when studying the pathophysiology and pharmacotherapy of inflammatory diseases. Expand
The Gender of Cell Lines Matters When Screening for Novel Anti-Cancer Drugs
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The findings revealed that 79 out of 81 of the compounds consistently inflicted higher levels of toxicity towards male derived cells, emphasizing that there is indeed a gender-related difference in cell sensitivity to these anti-neoplastic agents. Expand
Sexually-dimorphic targeting of functionally-related genes in COPD
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The ensemble approach to network analysis is believed to provide a principled way to capture sex-specific regulatory relationships and could be applied to identify differences in gene regulatory patterns in a wide variety of diseases and contexts. Expand
Sex-specific eNOS activity and function in human endothelial cells
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Sex-specific differences in the EC expression, activity, and function of eNOS are found and intrinsic sexual dimorphism of ECs should be further evaluated to achieve more effective and precise strategies for the prevention and therapy of diseases associated to an impaired endothelial function. Expand
Let's Talk About Sex-Biological Sex Is Underreported in Biomaterial Studies.
TLDR
In analyzing research articles from seven prominent biomaterials journals, sex as a biological variable is missing from an overwhelming majority of in vitro biomaterial studies and this leads to a gap in the understanding of sex-specific cell-biomaterial interactions. Expand
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