Biologics: an update and challenge of their pharmacokinetics.

@article{Shi2014BiologicsAU,
  title={Biologics: an update and challenge of their pharmacokinetics.},
  author={Shaojun Shi},
  journal={Current drug metabolism},
  year={2014},
  volume={15 3},
  pages={
          271-90
        }
}
Biologics, including but not limited to monoclonal antibodies (mAbs), cytokines, growth factors, enzymes, hormones, vaccines, antibody fragments (e.g. Fabs), and antibody drug conjugates (ADCs), have a powerful clinical impact on the management of a wide variety of diseases. When compared to small molecules (SMs), they have different physicochemical properties and demonstrate unique and complex pharmacokinetic (PK) characteristics that are dependent on several factors such as net charge… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

Factors Affecting the Pharmacology of Antibody–Drug Conjugates

VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Fluctuations in Pharmacokinetics Profiles of Monoclonal Antibodies

  • European Journal of Drug Metabolism and Pharmacokinetics
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

Overview of Antibody Drug Delivery

VIEW 2 EXCERPTS
CITES BACKGROUND