Biologically inspired strategies for combating bacterial biofilms.

  title={Biologically inspired strategies for combating bacterial biofilms.},
  author={Meghan S Blackledge and Roberta J. Worthington and Christian Melander},
  journal={Current opinion in pharmacology},
  volume={13 5},
Infections caused by bacterial biofilms are a significant global health problem, causing considerable patient morbidity and mortality and contributing to the economic burden of infectious disease. This review describes diverse strategies to combat bacterial biofilms, focusing firstly on small molecule interference with bacterial communication and signaling pathways, including quorum sensing and two-component signal transduction systems. Secondly we discuss enzymatic approaches to the… CONTINUE READING