Biologically erodable microspheres as potential oral drug delivery systems

@article{Mathiowitz1997BiologicallyEM,
  title={Biologically erodable microspheres as potential oral drug delivery systems},
  author={E. Mathiowitz and Jules S. Jacob and Yong S. Jong and G. Carino and D. Chickering and P. Chaturvedi and C. A. Santos and Kavita Vijayaraghavan and Sean Montgomery and M. Bassett and C. Morrell},
  journal={Nature},
  year={1997},
  volume={386},
  pages={410-414}
}
  • E. Mathiowitz, Jules S. Jacob, +8 authors C. Morrell
  • Published 1997
  • Biology, Medicine
  • Nature
  • Biologically adhesive delivery systems offer important advantages1–5 over conventional drug delivery systems6. Here we show that engineered polymer microspheres made of biologically erodable polymers, which display strong adhesive interactions with gastrointestinal mucus and cellular linings, can traverse both the mucosal absorptive epithelium and the follicle-associated epithelium covering the lymphoid tissue of Peyer's patches. The polymers maintain contact with intestinal epithelium for… CONTINUE READING
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