Biologically erodable microspheres as potential oral drug delivery systems

  title={Biologically erodable microspheres as potential oral drug delivery systems},
  author={E. Mathiowitz and Jules S. Jacob and Yong S. Jong and G. Carino and D. Chickering and P. Chaturvedi and C. A. Santos and Kavita Vijayaraghavan and Sean Montgomery and M. Bassett and C. Morrell},
  • E. Mathiowitz, Jules S. Jacob, +8 authors C. Morrell
  • Published 1997
  • Biology, Medicine
  • Nature
  • Biologically adhesive delivery systems offer important advantages1–5 over conventional drug delivery systems6. Here we show that engineered polymer microspheres made of biologically erodable polymers, which display strong adhesive interactions with gastrointestinal mucus and cellular linings, can traverse both the mucosal absorptive epithelium and the follicle-associated epithelium covering the lymphoid tissue of Peyer's patches. The polymers maintain contact with intestinal epithelium for… CONTINUE READING
    736 Citations
    Oral delivery of proteins by biodegradable nanoparticles.
    • 118
    Bioadhesive microspheres as a controlled drug delivery system.
    • 458
    Mucoadhesive systems in oral drug delivery.
    • 104
    Polymers for drug delivery systems.
    • 755
    Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?
    • 509


    Polymeric microspheres as drug carriers.
    • 143
    Bioadhesive Drug Delivery Systems
    • 135
    • PDF
    Poly(fumaric-co-sebacic) microspheres as oral drug delivery systems.
    • 58
    Biodegradable polymers as drug delivery systems
    • 729
    • PDF
    Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency
    • 770
    Novel Oral Drug Formulations
    • 59