Biologically erodable microspheres as potential oral drug delivery systems

@article{Mathiowitz1997BiologicallyEM,
  title={Biologically erodable microspheres as potential oral drug delivery systems},
  author={Edith Mathiowitz and Jules S. Jacob and Yong S. Jong and Gerardo P. Carino and Donald E. Chickering and Pravin Chaturvedi and Camilla A. Santos and Kavita Vijayaraghavan and Sean Montgomery and Michael Bassett and Craig N. Morrell},
  journal={Nature},
  year={1997},
  volume={386},
  pages={410-414}
}
Biologically adhesive delivery systems offer important advantages1–5 over conventional drug delivery systems6. Here we show that engineered polymer microspheres made of biologically erodable polymers, which display strong adhesive interactions with gastrointestinal mucus and cellular linings, can traverse both the mucosal absorptive epithelium and the follicle-associated epithelium covering the lymphoid tissue of Peyer's patches. The polymers maintain contact with intestinal epithelium for… 
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