Biologically active substituted benzodiazepines and their effect on cardiovascular and central nervous system.

@article{Shukla2001BiologicallyAS,
  title={Biologically active substituted benzodiazepines and their effect on cardiovascular and central nervous system.},
  author={Sumit Shukla and Upama Misra and Megha Bhalla and D K Mukerjee and Anil K Saxena and Jwala Nand Prasad Sinha and Kanne Shanker},
  journal={Bollettino chimico farmaceutico},
  year={2001},
  volume={140 1},
  pages={53-8}
}
Some substituted 1,5-benzodiazepine derivatives (including a spirocyclopentane moiety) were synthesized (Table I) and evaluated for their hypotensive and CNS activities respectively. The compounds which showed promising cardiovascular activity also exhibited marked anti-depressant action (Table II,III,IV). All the compounds showed higher ALD50 value.