Biologically active quinone and hydroquinone sesquiterpenoids from the sponge smenospongia sp.

  title={Biologically active quinone and hydroquinone sesquiterpenoids from the sponge smenospongia sp.},
  author={Marie-Lise Kondracki and M. Guyot},
Abstract This work describes isolation, structure and biological activity of quinone- and hydroquinone sesquiterpenoids biosynthesized by a sponge Snenospongia sp. Structures were established by spectral methods. All the products exhibited antimicrobial and cytotoxic activities. 
A new sesquiterpene tetronic acid derivative from the marine sponge Smenospongia sp
A new sesquiterpene tetronic acid derivative, named smenotronic acid 2 was isolated from the Red Sea marine sponge Smenospongia sp. Its structure was assigned by detailed spectroscopic analysis.
Nakijiquinones A and B, new antifungal sesquiterpenoid quinones with an amino acid residue from an Okinawan marine sponge
Abstract Two new sesquiterpenoid quinones with an amino acid residue, nakijiquinones A (1) and B (2), have been isolated from an Okinawan marine sponge
Cyclosmenospongine, a new sesquiterpenoid aminoquinone from an Australian marine sponge Spongia sp.
A new sesquiterpenoid aminoquinone, cyclosmenospongine (1), containing a dihydropyran ring, was isolated from an Australian marine sponge Spongia sp., along with the known metabolites,Expand
Cytotoxic Terpene Quinones from Marine Sponges
The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives. Expand
Smenoqualone a novel sesquiterpenoid from the marine sponge Smenospongia sp.
Abstract Smenoqualone, a novel quinonic terpenoid with a rearranged drimane skeleton was isolated from a marine sponge Smenospongia sp. The stereostructure was determined by detailed analyses of 1 HExpand
Synthetic Strategies to Terpene Quinones/Hydroquinones
The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and -hydroquinones from sponges offer promising opportunities for the development of new drugs. A review dealingExpand
A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria
Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxy-polyfibrospongol B, along with five known compounds, which displayed moderate inhibitory activity on HIV-1 RT. Expand
Bioactive Marine Prenylated Quinones/Quinols
Abstract Prenylated hydroquinones and related metabolites have been isolated from marine organisms with a terpenoid portion that ranges from one to nine isoprene units. Triprenyl- andExpand
Sesquiterpene quinones as immunomodulating agents.
Biological studies revealed products modulating immune responses in sesquiterpene quinones and hydroquinones isolated from the sponge Smenospongia sp, which revealed different behaviours on normal cells. Expand
New Meroterpenoids from the Marine Sponge Aka coralliphaga
Three new sulfated meroterpenoids containing sesquiterpene and hydroquinone moieties, namely siphonodictyal A sulfate, akadisulfate A and akad isulfate B were isolated from the sponge Aka coralliphaga and showed a radical-scavenging activity comparable with that of the known lipophylic antioxidant BHT. Expand


Ilimaquinone, a sesquiterpenoid quinone from a marine sponge
Abstract Ilimaquinone (1) is a new sponge metabolite of composition C22H30O4. Its structure, which was determined by spectral correlations and X-ray crystallography, comprises a rearranged drimaneExpand
Smenospongine: A cytotoxic and antimicrobial aminoquinone isolated from Smenospongia sp.
Abstract Smenospongine a cytotoxic and antimicrobial sesquiterpene-aminoquinone was isolated from Smenospongia sp. Structure elucidation was achieved by spectral analysis.
Inhibition of mitosis by avarol, a natural product isolated from the sponge Dysidea avara.
In vitro studies applying the methods of viscosimetry and electron microscopy demonstrate that avarol inhibits assembly of brain microtubule protein at an at least stoichiometric concentration ratio, and evidence is presented that the new antimitotic agent avarl inhibits protofilament elongation rather than lateral association of tubulin during protofILament formation. Expand
Biphasic and differential effects of the cytostatic agents avarone and avarol on DNA metabolism of human and murine T and B lymphocytes.
It was elucidated that at low concentrations avarone and avarol caused a stimulation of dThd incorporation only in LPS or PWM-activated lymphocytes, and it is assumed that both antileukemic agents also affect differentially the different hematologic neoplasms. Expand