Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K.

@article{Lin2014BiologicallyAL,
  title={Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K.},
  author={Hung-Yun Lin and Sheng-Huei Yang and Heng-Yuan Tang and Guei-Yun Cheng and Paul J. Davis and P. A. Grasso},
  journal={Peptides},
  year={2014},
  volume={57},
  pages={95-100}
}
The effects of leptin-related synthetic peptides [d-Leu-4]-OB3 and OB3 on energy balance and glucose homeostasis in ob/ob and db/db mice have been confirmed. The molecular basis of these effects, however, remains unclear. In the present study, we examined the ability of these peptides to activate signal transduction pathways known to be involved in transduction of the leptin signal. In a specific and concentration-dependent manner, [d-Leu-4]-OB3 induced phosphorylation of ERK1/2, PI-3K, Ser-727… CONTINUE READING

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