Biologically active dihydropyrimidones of the Biginelli-type--a literature survey.

  title={Biologically active dihydropyrimidones of the Biginelli-type--a literature survey.},
  author={C. Oliver Kappe},
  journal={European journal of medicinal chemistry},
  volume={35 12},
In 1893, the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via three-component condensation reaction of an aromatic aldehyde, urea and ethyl acetoacetate was reported for the first time by P. Biginelli. In the past decades, such Biginelli-type dihydropyrimidones have received a considerable amount of attention due to the interesting pharmacological properties associated with this heterocyclic scaffold. In this review, we highlight recent developments in this area, with a… CONTINUE READING

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