Biologically active biotin derivatives of schweinfurthin F.

  title={Biologically active biotin derivatives of schweinfurthin F.},
  author={Natalie Christine Ulrich and Craig Heath Kuder and Raymond J. Hohl and David F. Wiemer},
  journal={Bioorganic \& medicinal chemistry letters},
  volume={20 22},
As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity. 
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